ĐẶC ĐIỂM MÔ BỆNH HỌC SAU MỔ VÀ MỐI LIÊN QUAN VỚI THỜI GIAN SỐNG THÊM Ở BỆNH NHÂN UNG THƯ ĐẠI TRÀNG

Abstract

Objective: To describe postoperative histopathological characteristics and analyze their association with overall survival in patients with colon cancer undergoing curative resection. Participants and

Methods: This retrospective descriptive study was conducted on 409 patients diagnosed with colon adenocarcinoma who underwent curative surgery at the Department of Gastrointestinal Surgery, Viet Duc University Hospital, from January 2015 to December 2022.

Results: The mean age was 61.48 ± 13.50 years, with a male-to-female ratio of 1.3:1. Most patients were diagnosed at an advanced stage, with T3–T4 tumors accounting for 88.8% and stage II–III for 90%. The mean number of retrieved lymph nodes was 14.64 ± 8.75, with 58.9% achieving ≥ 12 nodes; the lymph node metastasis rate was 40.1%. The estimated 5-year overall survival (OS) was 72.1%. Survival was significantly lower in patients with deeper tumor invasion, lymph node metastasis, and higher LNR and LODDS levels (p < 0.05). Patients with ≥ 9 retrieved lymph nodes had better 5-year survival compared to those with < 9 nodes (p = 0.005).

Conclusions: Postoperative histopathological features, particularly tumor invasion depth, lymph node status, and lymph node–based indices (LNR, LODDS), are closely associated with overall survival in colon cancer patients. Adequate lymph node retrieval plays an important role in accurate staging and prognosis.