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Date Published: 19/12/2024
Abstract Views: 37
Views PDF: 8
DOI: 10.52322/jocmbmh.143.0207
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Vol. 2 No. 143 (2024)
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Hoang Thi, H., Nguyen Tuan, T., Pham Quang, V., Vu Minh, P., Ta Van, T., & Hoang Lan, A. (2024). OUTCOMES OF CYCLOSPORIN A AND ANTI THYMOCYTE GLOBULIN FOR APLASTIC ANEMIA AT BACHMAI HOSPITAL. Journal of Clinical Medicine Bach Mai Hospital, 2(143), 49-57. https://doi.org/10.52322/jocmbmh.143.0207

OUTCOMES OF CYCLOSPORIN A AND ANTI THYMOCYTE GLOBULIN FOR APLASTIC ANEMIA AT BACHMAI HOSPITAL

Hue Hoang Thi1, , Tung Nguyen Tuan2, Vinh Pham Quang2, Phuong Vu Minh1, Tuan Ta Van2, Anh Hoang Lan2
1 Trường Đại học Y Hà Nội
2 Bach Mai Hospital

Author contact

  • Contact information: Hue Hoang Thi
  • Email: hoanghuehhtm@gmail.com
  • Address: Trường Đại học Y Hà Nội

Main Article Content

Abstract

Objective: ATG plus CSA is a standard treatment for patients with aplastic anemia not suitable for allogeneic hematopoietic stem cell transplantation. With an aim generate more data on the efficacy of this regimen we have conducted a descriptive study. Participants and Methods: A longitudial observation study on patients with aplastic anemia treated with ATG and CSA at Bachmai Hospital from 1/2020 to 6/2024. Results: Analysed 22 patients with aplastic anemia treated with ATG and CSA, in which 12 ones used horse ATG (thymogam), 10 ones used rabit ATG (Grafalon). Overall response rates were 52 %, 79%, and 81% at 3-, 6- and 12-months post-treatment initiation, respectively. Complete response was achieved in 9%, 21%, and 25% at 3-, 6- and 12-months, respectively. No ones relapsed after treatment. In horse ATG, overall response is 100 % at 12 month. Most common side effects were mild kidney failure and swollen gums. Conclusion: The finding of this study reveals that the regimen of ATG and CSA is effective and safe in treating patients with aplastic anemia especially horse ATG and CSA at Bachmai Hospital.

Keywords

Aplastic anemia, ATG and CSA therapy

Article Details

References

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