Mối liên quan giữa một số chỉ số đông máu với hoạt động của bệnh lupus ban đỏ hệ thống ở phụ nữ mang thai

Abstract

SYSTEMIC LUPUS ERYTHEMATOSUS IN PREGNANT PATIENTS

Objectives: To describe some coagulation indices in systemic lupus erythematosus (SLE) patients in pregnacy and their relationship with disease activity.

Participants and

Methods: Cross-sectional study conducted on 82 pregnant SLE patients. Patients were evaluated for coagulation indices including: prothrombin ratio, APTT ratio, concentration of fibrinogen, D dimer and fibrin monomer. Assess disease activity according to SLEPDAI score (SLE Pregnancy Disease Activity Index).

Results: In lupus pregnancies, prothrombin, APTT, Fibrinogen, D dimer and fibrin monomer concentrations are 111,1 ± 13,5 %; 1,01 ± 0,15; 4,29 ± 1,17 g/l; 1,498 ± 1,359 µg/ml and 9.39 ± 16.02 µg/ml, respectively, the percentage of elevated concentration above the reference threshold of 2%, 4%, 62.2%, 81.7% and 23.2%, respectively. Log10 transformer of D dimer is positively correlated with gestational age, anti-dsDNA concentration and SLEPDAI score, log10 transformer of fibrin monomer dimer is positively correlated with gestational age and SLEPDAI. Multivariate regression analysis indicates that log10 transformed fibrin monomer along with complement C3 concentration and anti-dsDNA antibodies are factors that independently affect SLEPDAI scores in pregnant women.

Conclusions: Fibrinogen and D dimer levels were increased above the threshold in 62.2% and 81.7% of pregnant SLE patients, respectively. Fibrin monomer concentration is more specific than D dimer in assessing disease activity in pregnant women with SLE.